As the outermost barrier organ, the skin encounters environmental and pathogenic challenges immediately after birth. While it shares similarities with the immune systems of other barrier tissues, such as the lung and intestine, skin immunity has unique properties essential to the skin's physiological functions. Proper maturation prepares our skin to establish its immune response and create protective barriers against external threats. During the dynamic developmental stage, the immune system not only becomes a part of the skin's biology but also forms a variety of cellular networks specific to skin development, allowing us to peacefully coexist with microbes and the environment. For instance, specialized immune cells are layered in developing skin within specific developmental time frames to ensure the maintenance of tissue equilibrium and the normal functioning of the skin for growth and development. Any failure in one or more components of the skin's immune system increases the risk of susceptibility to infection, inflammation, and autoimmunity. This is especially true for newborns and infants, who still face high mortality rates worldwide, even in modern times. Many neonatal infections, such as neonatal sepsis, are associated with poorly developed skin barrier integrity, emphasizing the importance of studying early-life skin immunity. We use mouse models in our laboratory to study infectious and autoimmune diseases. Our goal is to understand the cellular and molecular factors that control the interaction between skin physiology and immune cells early in life. Specifically, we will explore the role of innate lymphocytes in the skin's immune system and how skin inflammation shapes the development and regulation of innate lymphocyte-mediated immune responses. Our mission is to bridge critical gaps in our understanding of the interconnectedness of the immune and cutaneous systems to pave the way for breakthroughs in managing a spectrum of skin disorders, from dermatitis and psoriasis to skin cancers.